I thought I'd post a few tips that will help people get the cleanest possible RAW files, and post-processing (noise reduction) that will help even more. Add your own findings and opinions!
I have found what some other people found, which is that sometimes even low ISO (ISO 100, ISO 80) files are overly noisy, here are some tips for an entire workflow:
1) Shoot at the lowest possible ISO setting. I have found that overriding the ISO to ISO 50 works often (it works on my Powershot A640 and Powershot SX130 IS). However, the lowest native ISO is just fine too.
-If you choose ISO 50, remember to compensate your exposure accordingly. I find it easiest to use the camera's ISO 100 setting and set the exposure dial to +1 (then use CHDK to override to ISO 50).
2) Experiment with overexposing the image (Google "expose to the right").
Simply put, you overexpose the image a certain amount (I overexpose by one stop), which will result in a cleaner RAW file. The value you can overexpose by without blowing out the highlights varies from camera to camera... I dont think you will get very different results from me (using a point and shoot camera, dSLR cameras are more flexible). If you are shooting a scene where you are already in danger of blowing out the highlights, then do not overexpose the image.
3) When you open the RAW (DNG) file on your computer, reduce the exposure setting in Camera Raw or other program, by the amount that you overexposed by. Or simply darken the image with the exposure setting until the exposure is correct and there are no highlights being blown.
4) Noise reduction. I use Noise Ninja to reduce noise, but there are other programs out there.
To get even better performance from Noise Ninja than the standard settings, make a camera profile for each ISO setting on your camera. This involves photographing a chart at each ISO setting, and putting the images through the program. Use the profile for the ISO setting you shot with when you reduce noise from that image. You can read more about that in the manual for Noise Ninja.
5) Optional: Depending on your needs, if you do not need full resolution, resize your image to a smaller size. I find viewing at 100% shows a certain amount of noise. Resizing to 50% gives a perfect picture if using a low ISO. Resizing to 25% gives good results with the high ISO files.
That's it!
I'll post a couple images so you can judge for yourself
Here are 3 DNG images straight out of the camera, as well as 3 PNG images made from those DNG after I have applied my workflow (correct exposure, noise reduction and sharpening). EDIT: I needed to do more sharpening.... I'm still perfecting my workslow.
http://www7.zippyshare.com/v/14641985/file.html (80MB) 3 random pics I took indoors to test my workflow.